Socio-Demographic Characteristics, Clinical Determinants, Psychosocial Perceptions,and Service Accessibility Among Patients Undergoing Assisted Reproductive Technology in Benin City, Nigeria
Keywords:
Accessibility, Assisted Reproductive Technology, Benin City, Fertility care, Infertility, IVF, Nigeria, Patient satisfaction, Reproductive health, StigmaAbstract
Assisted reproductive technology (ART), particularly in-vitro fertilization (IVF), has expanded the therapeutic options available to people experiencing infertility, access remains highly unequal. The objective of this study was to assess the socio-demographic characteristics, clinical and reproductive determinants, psychosocial perceptions, service accessibility, treatment experience, and patient recommendations among individuals undergoing ART in Benin City, Nigeria. A descriptive cross-sectional survey was conducted among 150 patients undergoing ART in Benin City between Dec 2024 and Dec. 2025 in the IVF unit of Department of Obstetrics and Gynaecology Edo Specialist Hospital Benin City using consecutive sampling technique to recruit participants with ethical approval number CMS/REC/2026/906 while statistical software SPSS version 26 was used for analysis. The mean age of respondents was 36.2 years (range 23–47 years). Females constituted 90.0% (n=135) and males 10.0% (n=15). Half of the respondents were aged 30–39 years, while 40.0% were aged 40–49 years. All respondents were married. Secondary education was reported by 56.7%, while 43.3% had tertiary education. Most respondents were self-employed (66.7%), and 63.3% reported monthly earnings of at least NGN 200,000. Rural residents constituted 53.3% of the sample. Clinically diagnosed infertility was documented in 93.3%, with secondary infertility accounting for 93.3% of respondents. IVF alone was the predominant treatment modality (93.3%). A substantial majority (83.3%) perceived ART as culturally unacceptable within their social environment, while none reported publicly disclosing their ART treatment. Personal privacy was the most frequently cited reason for non-disclosure (76.7%), followed by fear of social stigma (23.3%). Accessibility was perceived as difficult by 76.7% and very difficult by 23.3%. Despite these barriers, 86.6% rated their clinical experience as satisfactory or very satisfactory, and 93.3% would recommend the fertility centre to others. Conclusively ART patients in this Benin City study were predominantly women in their thirties and forties, married, economically active, and affected mainly by secondary infertility. Improving access to ART in Nigeria will require cost-reduction strategies, public or insurance-based financing, decentralization of fertility services, strengthening of specialist and laboratory capacity, confidential patient-centred care, and culturally sensitive psychosocial support.
References
1. Guideline for the prevention, diagnosis and treatment of infertility [Internet]. Geneva: World Health Organization; 2025. Available from: https://www.ncbi.nlm.nih.gov/books/NBK620423/
2. Mburu G, Santesso N, Brignardello-Petersen R ...Recommendations from the WHO guideline for the prevention, diagnosis, and treatment of infertility, Fertility and Sterility, 2025; 125, 880-894
3. Esteves S, Pacey A, De Jonge C; Paternal reproductive health in focus: new World Health Organization infertility guideline interpreted through a biological and clinical lens Reproductive BioMedicine Online, 2026; 52
4. Ezeome IV, Akintola SO, Jegede AS. Experiences of female clients in the assisted reproductive technology process in Nigeria. Afri Health Sci. 2023;23(2):659-69. https://dx.doi.org/10.4314/ahs.v23i2.76
5. Lemonu KM, Gbogbo J. Infertility: lived experiences of couples seeking fertility treatment in selected hospitals in Lagos State, Nigeria. Journal of Public Health and Toxicological Research. 2024;2(1):56–60.
6. Whittaker A, Gerrits T, Hammarberg K, Manderson L. Access to assisted reproductive technologies in sub-Saharan Africa: fertility professionals' views. Sex Reprod Health Matters. 2024 Dec;32(1):2355790. doi: 10.1080/26410397.2024.2355790. Epub 2024 Jun 12. PMID: 38864373; PMCID: PMC11172248.
7. Koigi P, Tripathi A. Uptake and outcomes of mild ovarian stimulation for in-vitro fertilization in Africa: a systematic review. Journal of Obstetrics and Gynaecology of Eastern and Central Africa. 2024;36(1). doi:10.59692/jogeca.v36i1.188.
8. African Network and Registry for ART. Assisted reproductive technologies in Africa: the African Network and Registry for ART, 2020. Reproductive BioMedicine Online. 2024. doi:10.1016/j.rbmo.2024.104353.
9. Fadare RI, Ogbujiagba VC, Bello CB, Ogbeye GB, Fadare OE. Women's perspectives regarding in vitro fertilization as a conception option at the primary healthcare level in Ekiti State. Res Health Serv Reg. 2026 Jun 11;5(1):9. doi: 10.1007/s43999-026-00093-5. PMID: 42274942; PMCID: PMC13260560.
10. American Society for Reproductive Medicine. Fertility evaluation of infertile women: a committee opinion. Fertility and Sterility. 2021;116:1255–1265.
11. Amadi L, Raji FO, Odelola OI. The effects ofinfertility on the quality of life of women: Acomparative study in a Nigeriantertiary centre. Niger J Med 2025;34:38-44.
(PDF) The Effects of Infertility on the Quality of Life of Women: A Comparative Study in a Nigerian Tertiary Centre. Available from: https://www.researchgate.net/publication/392014990_The_Effects_of_Infertility_on_the_Quality_of_Life_of_Women_A_Comparative_Study_in_a_Nigerian_Tertiary_Centre [accessed Sep 22 2026].
12. Schlegel PN, Sigman M, Collura B, De Jonge CJ, Eisenberg ML, Lamb DJ, Mulhall JP, Niederberger C, Sandlow JI, Sokol RZ, Spandorfer SD, Tanrikut C, Treadwell JR, Oristaglio JT, Zini A. Diagnosis and treatment of infertility in men: AUA/ASRM guideline part I. Fertil Steril. 2021 Jan;115(1):54-61. doi: 10.1016/j.fertnstert.2020.11.015. Epub 2020 Dec 9. PMID: 33309062.
13. Shi Z, Zheng Y, Mao Z, Nie H, Chen G, Li S. Design and selection of items for a new health-related quality of life instrument with infertility patients (Infertility-QoL): a national multicenter, four-phase, mixed-methods study. Health Qual Life Outcomes. 2025 Sep 26;23(1):88. doi: 10.1186/s12955-025-02416-5. PMID: 41013678; PMCID: PMC12465535.
14. ESHRE Add-ons working group, K Lundin, J G Bentzen, G Bozdag, T Ebner, J Harper, N Le Clef, A Moffett, S Norcross, N P Polyzos, S Rautakallio-Hokkanen, I Sfontouris, K Sermon, N Vermeulen, A Pinborg, Good practice recommendations on add-ons in reproductive medicine, Human Reproduction, Volume 38, Issue 11, November 2023, Pages 2062–2104, https://doi.org/10.1093/humrep/dead184.
15. The ESHRE Guideline Group on Ovarian Stimulation , B Ata, E Bosch, S Broer, G Griesinger, M Grynberg, E Kolibianakis, M Kunicki, A La Marca, G Lainas, N Le Clef, N Massin, N P Polyzos, S K Sunkara, T Timeva, M Töyli, J Urbancsek, F Broekmans, ESHRE guideline: ovarian stimulation for IVF/ICSI: an update in 2025, Human Reproduction, Volume 41, Issue 4, April 2026, Pages 498–514,
16. Njogu A, Njogu J, Mutisya A, Luo Y. Experiences of infertile women pursuing treatment in Kenya: a qualitative study. BMC Women's Health. 2022;22:364.
17. Sharma A, Shrivastava D. Psychological problems related to infertility. Cureus. 2022;14(10):e30320.
18. Chimbatata, N.B.W. and Malimba, C. (2016) Infertility in Sub-Saharan Africa: A Woman's Issue for How Long? A Qualitative Review of Literature. Open Journal of Social Sciences, 4, 96-102. DOI: 10.4236/jss.2016.48012
19. Mthembu N. Beyond reproductive rights: advocating for access to assisted reproductive technologies for socially infertile individuals using the right to benefit from scientific progress—lessons for African countries. South African Journal of Bioethics and Law. 2024;17(3). doi:10.7196/SAJBL.2024.v17i3.2061.
20. Practice Committee of the American Society for Reproductive Medicine. Improving access to care and delivery to marginalized and vulnerable populations: a committee opinion. Fertil Steril. 2025 Nov 15;124(5 Pt 2):974-984. doi: 10.1016/j.fertnstert.2025.08.003. Epub 2025 Sep 5. PMID: 40914668.